HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 1-(Bromomethyl)-3-methoxy-5-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3,5-Dimethylanisole | HCID 70126 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 1-(Bromomethyl)-3-methoxy-5-methylbenzene | HCID 585534 | 68% |
Reaction Steps
A suspension of 3,5-dimethylanisole (13.60 g, 100 mmol), N-bromosuccinimide (18.35 g, 100 mmol) and 2,2′-azobis(2-methylpropionitrile) in CCl4 was heated under reflux for 1 h. The succinimide was filtered off, the filtrate was concentrated and the residue was chromatographed (SiO2, CH2Cl2/hexane 1:4). There were obtained 14.61 g (68%) of 1-bromomethyl-3-methoxy-5-methyl-benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242644B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-10a65cbfb5ea4cdcabe444371a923be5 |
| Source note | uspto-grants-2001_06 |