反应详情

2-Nitropropane (6.77 ml, 71.3 mmol) and subsequently 1-bromomethyl-3-methoxy-5-methyl-benzene (14.6 g, 67.9 mmol) were added to a solution of NaOEt (4.72 g, 67.9 mmol) in EtOH (60 ml). The mixture was heated for 1.5 h. to 65° C. After cooling the colorless precipitate of filtered off and the filtrate was concentrated. The product was purified by chromatography (SiO2, CH2Cl2/hexane 1:2). There were obtained 7.87 g (77%) of 3-methoxy-5-methyl-benzaldehyde as a colorless liquid.

1. temperatureThe mixture was heated for 1.5 h. to 65° C
2. temperatureAfter cooling the colorless precipitate
3. filtrationof filtered off
4. concentrationthe filtrate was concentrated
5. customThe product was purified by chromatography (SiO2, CH2Cl2/hexane 1:2)