HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(Dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate → 4-Benzyl-6-(3,4-dichlorophenyl)-6-[2-[4-(2-dimethylaminothiazol-4-yl)-4-phenylpiperid-1-yl]ethyl]morpholin-3-one dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(Dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate | HCID 21200554 | — |
| Reactant | 4-Benzyl-6-(3,4-dichlorophenyl)-6-[2-(4-hydroxy-4-phenylpiperid-1-yl)ethyl]morpholin-3-one hydrochloride hemihydrate | HCID 131722622 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Benzyl-6-(3,4-dichlorophenyl)-6-[2-[4-(2-dimethylaminothiazol-4-yl)-4-phenylpiperid-1-yl]ethyl]morpholin-3-one dihydrochloride | HCID 21200598 | 223.7% |
Reaction Steps
This compound is prepared by the procedure described in EXAMPLE 41 from 1.1 g of the compound obtained in step B of EXAMPLE 14, 1.3 g of 4-[2-(dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate, 0.97 g of K2CO2 and 4 ml of DMF to give 0.76 g of the expected product. M.p.=155-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242637B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-d17ec7f175e84a24a1ed144b684ba398 |
| Source note | uspto-grants-2001_06 |