HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperid-1-yl]ethyl]morpholine hydrochloride monohydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperidine benzenesulfonate | HCID 21200475 | — |
| Reactant | 4-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-(N',N'-dimethylureido)-4-phenylpiperid-1-yl]ethyl]morpholine hydrochloride hemihydrate | HCID 131720058 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperid-1-yl]ethyl]morpholine hydrochloride monohydrate | HCID 21200640 | 47.3% |
Reaction Steps
This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperidine benzenesulfonate, 1.2 g of K2CO3 and 2 ml of DMF to give 0.3 g of the expected product. M.p.=163-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242637B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-fd7cc33bb7044f8491bfb4dd67387f93 |
| Source note | uspto-grants-2001_06 |