Pyridine → HCID 21195520, compound

HRID 1066705Notes

Reaction equation

HRID 1066705 reaction equation
[CH3:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[C:4]([C:8]([CH3:11])=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:17])=O.N1C=CC=CC=1>C1C=CC=CC=1>[CH3:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[C:4]([C:8]([CH3:11])=[CH:9][CH:10]=1)[C:5]([Cl:17])=[O:6]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 2676503,6-Dimethyl-2-nitrobenzoic acid

Product 1

HCID 21195520HCID 21195520, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3,6-Dimethyl-2-nitrobenzoic acid in an amount of 9.6 g (51 mmol) was dissolved in 100 ml benzene and then followed by an addition of thionyl chloride in an amount of 8.8 g (74 mmol) and pyridine in an amount of 0.1 lg. The mixture was then heated for 2 hours under reflux, and the solvent therein was distillated out under reduced pressure to obtain 3,6-dimethyl-2-nitrobenzoyl chloride in an amount of 10.3 g.

Workup

  1. temperatureThe mixture was then heated for 2 hours
  2. temperatureunder reflux

Sources & evidence

ORD record
ord-e0d45bf9cdb147f8bf56b389bd5c5555
Source dataset
uspto-grants-2001_06
Patent number
US06245716B1

Reaction notes

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