Acetic Anhydride → HCID 131722627, compound

Participants

Reaction Steps

The title compound was obtained by analogous manner as described in Example 18, but using BocTyr(PO3Et2)OH. The N-acetylation was performed by treatment of crude H—Tyr(PO3Et2)—Val—Asn—Val—NH2 with 1.5 equiv. of DIEA and 5 equiv. of acetic anhydride in DMF for 2 h at 25° C. The final compound was obtained with chromatographic purity (HPLC) of 90.0%. Amino acid ratios: Val 2 (2); Asx 1.17 (1); Tyr 0.87 (1). Peptide content: 83%. FAB mass spectroscopy; m/z 671 [M—H]+. (MW 670.1)

Provenance & Evidence