3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-Chloro-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 106673Notes

Reaction equation

HRID 106673 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1.[NH2:18][c:19]1[cH:20][c:21]([CH3:36])[c:22]([N:27]2[CH2:28][CH2:29][CH:30]([N:33]([CH3:34])[CH3:35])[CH2:31][CH2:32]2)[cH:23][c:24]1[O:25][CH3:26]>>[c:2]1([NH:18][c:19]2[cH:20][c:21]([CH3:36])[c:22]([N:27]3[CH2:28][CH2:29][CH:30]([N:33]([CH3:34])[CH3:35])[CH2:31][CH2:32]3)[cH:23][c:24]2[O:25][CH3:26])[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indoleHCID 580714601-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidin-4-amine

Product 1

HCID 580714995-Chloro-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-58c6ccbae7044565a59cd24eef244d37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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