反应详情

1-acetyl-5-bromo-7-chloroindoline (1.17 g) was dissolved in a mixture of ethanol (15 mL) and water (8 mL) containing KOH (0.5 g) and heated to reflux for 2 h. The reaction was partitioned between EtOAc (100 mL) and water (20 mL). The organic extract was washed with brine (20 mL), dried and stripped in vacuo to give 5-bromo-7-chloroindoline (0.87 g).

1. temperatureheated
2. temperatureto reflux for 2 h
3. customThe reaction was partitioned between EtOAc (100 mL) and water (20 mL)
4. extractionThe organic extract
5. washwas washed with brine (20 mL)
6. customdried