反应详情

3.0 g (16.4 mmol) of the compound from Example I are boiled under reflux for 17 hours in 250 ml of a saturated methanolic ammonia solution. The reaction mixture is evaporated in vacuo, the residue is taken up in methanol and the mixture is evaporated again; this process is repeated a few times. The crude product is taken up in dichloromethane and extracted several times with water. The aqueous phase is evaporated to a very great extent, an oil being obtained which crystallizes on standing.

1. customThe reaction mixture is evaporated in vacuo
2. customthe mixture is evaporated again
3. extractionextracted several times with water
4. customThe aqueous phase is evaporated to a very great extent
5. customan oil being obtained which
6. customcrystallizes on standing