反应详情

6-Methyl-3-nitro-5,6,7,8-tetrahydro[1,6]naphthyridine (2.72 g, 1.41 mmol) was dissolved in methanol (100 ml) and treated with 10% palladium on carbon (1.0 g). The mixture was hydrogenated for 2 h. The catalyst was removed by filtration through Celite, the filter bed washed with methanol and the filtrate evaporated to dryness under reduced pressure to give a yellow solid, which was triturated under diethyl ether and the solids collected by filtration, washed with diethyl ether and dried in vacuo (1.89 g, 83%)

1. customThe catalyst was removed by filtration through Celite
2. washthe filter bed washed with methanol
3. customthe filtrate evaporated to dryness under reduced pressure
4. customto give a yellow solid, which
5. customwas triturated under diethyl ether
6. filtrationthe solids collected by filtration
7. washwashed with diethyl ether
8. customdried in vacuo (1.89 g, 83%)