Sodium Hydroxide → 3-Chloro-4-(propan-2-yloxy)benzoic acid

HRID 1066773Notes

Reaction equation

HRID 1066773 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([CH3:15])[CH3:14])[C:5]([O:7]C)=[O:6].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([CH3:15])[CH3:14])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22597811Methyl 3-chloro-4-isopropoxybenzoate

Product 1

HCID 225977283-Chloro-4-(propan-2-yloxy)benzoic acidYield 83.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 3-chloro-4-iso-propoxybenzoate (5.5 g, 24.1 mmol) was hydrolysed using 1M NaOH (36 ml) in methanol (80 ml). Extraction and work-up with ethyl acetate gave the title compound (4.3 g).

Workup

  1. extractionExtraction

Sources & evidence

ORD record
ord-24be4a14385e4775ba73658f0c1da354
Source dataset
uspto-grants-2001_06
Patent number
US06245778B1

Reaction notes

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