3-Bromo-4-methoxybenzoyl chloride → N-(6-Methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-3-yl)-3-bromo-4-methoxybenzamide, monohydrochloride

Participants

Reaction Steps

3-Amino-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridine (300 mg; 1.84 mmol) was dissolved in dry tetrahydrofuran (10 ml) under argon and treated with a solution of 3-bromo-4-methoxybenzoyl chloride (459 mg; 1.84 mmol) in dry tetrahydrofuran (10 ml). The mixture was stirred at ambient temperatures for 18 h and the product (720 mg; 95%) collected by filtration washed with tetrahydrofuran and dried.

Provenance & Evidence