Formic Acid → HCID 21196174, compound

HRID 1066796Notes

Reaction equation

HRID 1066796 reaction equation
[Cl:1][C:2]1[CH:48]=[CH:47][C:5]([O:6][CH2:7][C:8]2[N:9]([CH3:46])[C:10]3[C:15]([C:16]=2[C:17]([CH2:19][CH2:20][CH:21]2[CH2:26][CH2:25][N:24](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH2:23][CH2:22]2)=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:9]([CH3:46])[C:10]3[C:15]([C:16]=2[C:17]([CH2:19][CH2:20][CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:47][CH:48]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 21195991HCID 21195991, compound

Product 1

HCID 21196174HCID 21196174, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Under an argon atmosphere 2-[(4-chlorophenoxy)methyl]-1-methyl-3-[[2-(1-tritylpiperidin-4-yl)ethyl]carbonyl]-1H-indole (0.2723 g, 0.417 mmol) was dissolved in 2.1 ml of methylene chloride. To this solution formic acid (0.079 ml, 0.096 g, 2.084 mmol) was added and the resulting mixture was stirred at room temperature for about 2.5 hours. The progress of the reaction was monitored by thin layer chromatography.

Sources & evidence

ORD record
ord-e05b707549d341e78ef69d1b80d00fcd
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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