N'-(3-(Dimethylamino)propyl)-N,N-dimethyl-1,3-propanediamine → 2-[(4-chlorophenoxy)methyl]-1-methyl-3-[[N,N-bis(3-dimethylaminopropyl)amino]carbonyl]-1H-indole

Participants

Reaction Steps

Under an argon atmosphere 2-[(4-chlorophenoxy)methyl]-1-methyl-3-carboxy-1H-indole (0.100 g, 0.317 mmol) was dissolved in 3.2 ml of N,N-dimethylformamide. To this solution were added N,N-bis(3-dimethylaminopropyl)amine (0.074 ml, 0.0623 g, 0.332 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.091 g, 0.475 mmol), and hydroxybenztriazole (0.0642 g, 0.475 mmol). The resulting mixture was then heated for 6 hours and then stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography.

Provenance & Evidence