HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[(2-Fluorophenyl)methoxy]-N-(1-methylethyl)-1-butanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine | HCID 21196084 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(2-Fluorophenyl)methoxy]-N-(1-methylethyl)-1-butanamine | HCID 21196198 | — |
Reaction Steps
The desired intermediate was prepared from the deprotection of 4-(2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine using standard techniques. The 4-(2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine was admixed with a 4:1 mixture of methylene chloride and trifluoroacetic acid. The progress of the reaction was monitored by thin layer chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06245761B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-00ccd20f8551458fb74118132f447919 |
| Source note | uspto-grants-2001_06 |