4-(2-fluoro-5-chlorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine → HCID 21196071, compound

HRID 1066812Notes

Reaction equation

HRID 1066812 reaction equation
FC1C=CC=CC=1COCCCCNC(C)C.[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([F:42])=[C:23]([CH:41]=1)[CH2:24][O:25][CH2:26][CH2:27][CH2:28][CH2:29][N:30](C(OC(C)(C)C)=O)[CH:31]([CH3:33])[CH3:32]>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([F:42])=[C:23]([CH:41]=1)[CH2:24][O:25][CH2:26][CH2:27][CH2:28][CH2:29][NH:30][CH:31]([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 211960964-(2-fluoro-5-chlorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamineHCID 211961984-[(2-Fluorophenyl)methoxy]-N-(1-methylethyl)-1-butanamine

Product 1

HCID 21196071HCID 21196071, compound

Procedure

The desired intermediate was prepared essentially as described for the 4-(2-fluorobenzyloxy)-N-(isopropyl)butylamine above, except that an equimolar amount of 4-(5-chloro-2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine was employed in place of the 4- (2-fluorobenzyloxy)-N-(t-butoxycarbonyl)-N-(isopropyl)butylamine employed therein.

Sources & evidence

ORD record
ord-2c61e34386054e578d1ce652738d1212
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

Loading…