6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-one → 7-bromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1066869Notes

Reaction equation

HRID 1066869 reaction equation
BrC1C=N[C:5]2[N:6]=[C:7]([O:14][CH2:15][CH2:16][CH3:17])[N:8]([CH2:11][CH2:12][CH3:13])[C:9](=[O:10])[C:4]=2C=1.BrC1C=NC2N=C(SCCC)N(CCC)C(=O)C=2C=1.IC1C=C2C(=CC=1)N=C(OCCC)N(CC1CCCO1)C2=O.BrC1C=C2C(=CC=1)N=C(OCCC)N(CC1CCCO1)C2=O.BrC1C=C2C(=CC=1)N=C(OCCC)N(CC1ON=C(Br)C1)C2=O.Br[C:107]1[S:115]C2C(=O)N(CCC)C(OCCC)=NC=2[C:108]=1[Br:124].IC1C=C2C(=C(I)C=1)N=C(SCCC)N(CC1CCCO1)C2=O.C1(CN2C(=O)C3C=C(I)C=NC=3N=C2SCCC)CC1>>[Br:124][C:108]1[C:5]2[N:6]=[C:7]([O:14][CH2:15][CH2:16][CH3:17])[N:8]([CH2:11][CH2:12][CH3:13])[C:9](=[O:10])[C:4]=2[S:115][CH:107]=1

Participants

9

Reactant 8

HCID 154523326-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-oneHCID 155103336-bromo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinoneHCID 155103376-bromo-3-propyl-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-oneHCID 155103413-(cyclopropylmethyl)-6-iodo-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-oneHCID 155103476-iodo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinoneHCID 211962726bromo-3-[(3-bromo-4,5-dihydro-5-isoxazolyl)methyl]-2-propoxy-4(3H)-quinazolinoneHCID 211962736,8-diiodo-2-(propylthio)-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinoneHCID 211962836,7-dibromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one

Product 1

HCID 211962787-bromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one

Procedure

6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-one; 6-bromo-3-propyl-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-one; 6-iodo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone; 6-bromo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone; 6bromo-3-[(3-bromo-4,5-dihydro-5-isoxazolyl)methyl]-2-propoxy-4(3H)-quinazolinone; 6,7-dibromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one; 6,8-diiodo-2-(propylthio)-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone; and 3-(cyclopropylmethyl)-6-iodo-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-one.

Sources & evidence

ORD record
ord-d2d6435e80454963b8500f1380e1d66f
Source dataset
uspto-grants-2001_06
Patent number
US06245770B1

Reaction notes

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