Sodium Hydroxide → HCID 21196741, compound

Participants

Reaction Steps

A 0.44 g of lithium aluminum hydride was suspended in 50 ml of tetrahydrofuran under argon atmosphere, a tetrahydrofuran (10 ml) solution containing 2.60 g of (1H-furo[2,3-g]indazol-1-yl)ethyl acetate was added dropwise, and the resulting mixture was stirred at room temperature for 1 hour. The reaction solution was cooled in an ice bath, methanol was added to decompose excess lithium aluminum hydride, and then 0.44 ml of water, 0.44 ml of 15% sodium hydroxide aqueous solution and 1.30 ml of water were added in that order. The resulting mixture was stirred for 30 minutes, anhydrous magnesium sulfate and celite were added, followed by stirring for 30 minutes. After removal of the insoluble matter by celite filtration, the filtrate was concentrated under a reduced pressure to give 1.82 g of 2-(1H-furo[2,3-g]indazol-1-yl)ethanol.

Provenance & Evidence