Ethyl Acetate → HCID 21196661, compound

Participants

Reaction Steps

To an ethyl acetate (10 ml) solution containing 0.46 g of 1-(1-t-butoxycarbonylazetidin-3-ylmethyl)-1H-furo[2,3-g]indazole was added 4 N hydrochloric acid ethyl acetate solution (3 ml), and the resulting mixture was stirred at room temperature for 4 hours. After evaporation of the solvent under a reduced pressure, the residue was extracted with chloroform and washed with 1 N sodium hydroxide and then the thus obtained organic layer was dried with anhydrous sodium sulfate. After removal of the drying agent, the solvent was evaporated and the residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate =5/1) and then treated with fumaric acid in methanol/ethyl acetate to give 0.19 g of 2-chloromethyl-3-(1H-furo[2,3-g]indazol-1-yl)propylamine fumarate.

Provenance & Evidence