HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluoroanisole | HCID 9987 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate | HCID 17935595 | — |
| Product | 4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester | HCID 17935610 | — |
Reaction Steps
0.8 g of anhydrous aluminum chloride is added to 5 ml of 4-fluoranisole and 0.9 g of 2-hydroxy-4-methylene-2-trifluoromethyl-valeric acid ethyl ester. After 40 hours of stirring at room temperature, it is added to ice-cooled 2N hydrochloric acid and extracted with ethyl acetate. The ethyl acetate phase is washed with 1N hydrochloric acid and water, dried (Na2SO4) and concentrated by evaporation. After chromatography on silica gel with hexane/ethyl acetate (1:1), 1 g of 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, melting point 38-39° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06245804B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-9b9c8251a8da48d6a0d930d619a8579a |
| Source note | uspto-grants-2001_06 |