HCID 15965859, compound → HCID 18551272, compound

HRID 1066948Notes

Reaction equation

HRID 1066948 reaction equation
BrC1C([NH:12]C(=O)C(=O)CC(C)(C2C=CC=CC=2)C)=CC=C2C=1COC2=O.[CH2:27]([C:29]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[C:32](=[O:39])[O:31][N:30]=1)[CH3:28].[F:40][C:41]1[CH:42]=[CH:43][C:44]([O:56][CH3:57])=[C:45]([C:47]([CH3:55])([CH3:54])[CH2:48][C:49](=[O:53])[C:50](O)=[O:51])[CH:46]=1>>[F:40][C:41]1[CH:42]=[CH:43][C:44]([O:56][CH3:57])=[C:45]([C:47]([CH3:55])([CH3:54])[CH2:48][C:49](=[O:53])[C:50]([NH:12][C:36]2[CH:37]=[CH:38][C:33]3[C:32](=[O:39])[O:31][N:30]=[C:29]([CH2:27][CH3:28])[C:34]=3[CH:35]=2)=[O:51])[CH:46]=1

Participants

4

Reactant 3

HCID 15965859HCID 15965859, compoundHCID 185512024-Bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalideHCID 18551274HCID 18551274, compound

Product 1

HCID 18551272HCID 18551272, compound

Procedure

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 4-ethyl-2,3-benzoxazin-1-one and 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxo-valeric acid, melting point 157-158° C.

Workup

  1. customwas obtained analogously to the process that

Sources & evidence

ORD record
ord-c4e9fc46a7a34b4095c1e680697c59f3
Source dataset
uspto-grants-2001_06
Patent number
US06245804B1

Reaction notes

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