Methanol → HCID 22725164, compound

HRID 1066965Notes

Reaction equation

HRID 1066965 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[CH2:12][CH2:11][N:10]([C:13]2C(CC(O)C)=CC=C3C([NH:18][C:19](=O)[C:14]=23)=O)[CH2:9][CH2:8]1.NN.C[OH:31]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH:14]([OH:31])[CH2:19][NH2:18])[CH2:9][CH2:8]1

Participants

4

Reactant 3

HCID 887MethanolHCID 9321HydrazineHCID 22725178HCID 22725178, compound

Product 1

HCID 22725164HCID 22725164, compoundYield 98%

Procedure

A mixture of 3-[4-(2-pyridyl)-piperidin-1-yl](2-hydroxypropyl)phthalimide (1.35 g, 3.68 mmol) and hydrazine (0.588 g, 18.4 mmol) in methanol (15 mL) was stirred and refluxed for 4.5 h. It was cooled, filtered, and the solid was washed with methanol (30 mL). Evaporation of solvent from the filtrate gave the product as a viscous oil (0.85 g, 98%).

Workup

  1. temperaturerefluxed for 4.5 h
  2. temperatureIt was cooled
  3. filtrationfiltered
  4. washthe solid was washed with methanol (30 mL)
  5. customEvaporation of solvent from the filtrate

Sources & evidence

ORD record
ord-bbb2bec01778402c8742d6cdd6196995
Source dataset
uspto-grants-2001_06
Patent number
US06245773B1

Reaction notes

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