N-(1-(Benzyl)-4-piperidyl)benzamide → N-4-Piperidylbenzamide

HRID 1066984Notes

Reaction equation

HRID 1066984 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[C:15]([NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)(=[O:22])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 1

HCID 40598N-(1-(Benzyl)-4-piperidyl)benzamide

Product 1

HCID 118120N-4-PiperidylbenzamideYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

To a suspension of 10% palladium on carbon (0.2 g) in 30 mL of ethyl alcohol was added a solution of 1-benzyl-4-benzamido-piperidine (0.5 g, 1.79 mmol) in ethyl alcohol (10 mL). The resulting suspension was hydrogenated at 100 psi at 50° C. for 30 h after which it was filtered through a pad of celite and the solvent was removed in vacuo to obtain 0.34 g (100%) of 4-benzamidopiperidine as a white solid. It was used in the next step without purification.

Workup

  1. filtrationafter which it was filtered through a pad of celite
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2f29796371034863a69c1bad23542458
Source dataset
uspto-grants-2001_06
Patent number
US06245773B1

Reaction notes

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