Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Dibenz(b,f)azepine | HCID 9212 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Phosphoric Acid | HCID 1004 | — |
| Product | Carbamazepine | HCID 2554 | — |
Reaction Steps
To a suspension of urea (80 g, 1.333 mols) in acetic acid (100 ml), phosphoric acid (8 ml) was added, followed by iminostilbene (20 g, 0.103 mols), under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06245908B1 |
|---|
| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-4ac90fca99bf43eb8cf1417bbe33bd96 |
|---|
| Source note | uspto-grants-2001_06 |
|---|
