Dimethyl Sulfate → 3,5-Dimethyl-4-nitropyridine-N-Oxide dimethyl Sulphate

Participants

Reaction Steps

To a suspension of 3,5-Dimethyl-4-nitropyridine-N-Oxide (V) (150 gm, 0.80 mole) in acetone (450 ml) was added dimethyl sulfate (90 ml, 0.95 mole). The mixture was heated to reflux until a clear solution was obtained and then allowed to cool to ambient temperature. An off-white crystalline solid separated out, which was filtered, washed with acetone and dried to yield 220 gm of the adduct. Yield was 83.8% of theoretical.

Provenance & Evidence