Hydrogen Peroxide → HCID 178488147, compound

Participants

Reaction Steps

To a solution of 5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridinyl)methylthio]-1H-benzimidazole (11) (32.9 gm, 0.1 mole) in dichloromethane (200 ml) was added phthalic anhydride (20 gm, 0.135 mole) and cooled in an ice salt bath. This was followed by addition of sodium carbonate (18 gm, 0.17 mole) and water (20 ml). Hydrogen peroxide (12 ml, 45%, 0.16 mm mole) was added dropwise at −5 to 0° C. and the reaction mixture was stirred at the same temperature. When the reaction was complete as indicated by TLC, water (200 ml) was added, cooling bath was removed and the reaction mixture was stirred for 10 mins. The organic layer was separated and washed with 5% sodium carbonate solution. The separated dichloromethane solution was charcolised and filtered through celite. The filtrate was concentrated to 100 ml and ethyl acetate 100 ml was added thereto. The separated solid was filtered, washed with ethyl acetate and dried in vacuum oven to yield 28.20 gm of Omeprazole. Yield 82.4% of theoretical. Melting Point was 158-160° C. (dec.)

Provenance & Evidence