Water → HCID 15044216, compound

Participants

Reaction Steps

Following the method of Krepski et al., Tetrahedron Lett., 1983, 24, 4075-78, 185 mL of a 3.0 M phenylmagnesium bromide solution in diethyl ether (Aldrich) was added to a stirred solution of 143 g (0.49 mol) 4-trimethylsilyloxy-α-trimethylsilyloxyphenylacetonitrile from Example 54 in 1.0 L diethyl ether at 0° C. When addition was complete, the solution was allowed to stand at room temperature overnight before 50 mL water was added slowly.

Provenance & Evidence