Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → benzyl (2S)-2-amino-3-methylbutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | 5'-Phospho-2'-deoxyribocytidylylriboadenosine | HCID 195511 | — |
| 반응물 | 4-Pentenoic anhydride | HCID 2733439 | — |
| 반응물 | N-(N-benzyloxycarbonyl-2-amino-4-Pentenoyl)-L-valine benzyl ester | HCID 20662988 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | benzyl (2S)-2-amino-3-methylbutanoate | HCID 6950584 | 94% |
반응 단계
N-(4-pentenoyl)valyl-pdCpA was prepared. Treatment of S-valine methyl ester with 4-pentenoic anhydride afforded the respective amide as a colorless oil in 73% yield. Following hydrolysis of the ester moiety (LiOH, aq THF), the derived intermediate was converted to the respective cyanomethyl ester (4). Admixture of 4 and pdCpA Robertson, et al., Nucleic Acids Res. 17:9649 (1989), in freshly distilled DMF afforded N-(4-pentenoyl)valyl-pdCpA (5) as a colorless solid in 94% yield. A sample of N-(2-nitroveratryloxycarbonyl)valyl-pdCpA was prepared as described, Robertson, et al., J. Am. Chem. Soc. 113:2722 (1991) for comparative purposes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06245938B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-b9b01da9b23a47ad8e081d38b9ec2dc2 |
| 출처 메모 | uspto-grants-2001_06 |