(2S)-2-(((tert-butoxy)carbonyl)amino)-4-phenylbutanoic acid → HCID 131722642, compound

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Reaction Steps

Using Procedure D, Boc-homophenylalanine (143 mg) and Nδ-Boc-Nα-methylornithine 2-(4-fluorophenyl)ethylamide (B) (crude product) gave desired compound (195 mg) as a glassy solid which was purified by flash chromatography: 1H NMR (400 MHz, CDCl3) δ1.52 (2 s, 18H).1.71 (m, 2H), 1.82 (m, 4H), 2.62-2.80 (m, 7H), 3.12 (m, 2H), 3.45 (m, 2H), 4.61 (m, 1H), 4.92 (m, 1H), 6.89 (m, 2H), 7.13 (m, 2H), 7.20 (m, 3H), and 7.32 (m, 2H).

Provenance & Evidence