Trifluoroacetic acid → HCID 21970616, compound

Participants

Reaction Steps

Boc-β-(1-Naphthyl)alanyl-Nδ-Fmoc-Nα-methylornithine benzylamide (B) (28 mg) was deprotected in teo steps-i) 20% piperidine in dimethylformamide and ii) trifluoroacetic acid exposure to afford a white solid: HPLC (method A); 1H NMR (400 MHz, D2O) δ1.59 (m, 2H), 1.77 (m, 1H), 1.89 (m, 1H), 2.38 (s, 3H), 3.0 (t, 2H), 3.60 (dd, 1H), 3.82 (dd, 1H), 4.39 (d, 2H), 4.92 (t, 1H), 5.01 (dd, 1H), 7.36-7.50 (m, 12H), 7.75 (m, 2H), 7.99 (t, 1H),8.10 (d, 1H), and 8.18 (d, 1H).

Provenance & Evidence