Boc-D-Phenylalanyl-Ndelta-CBz-Ornithinyl 2-Benzothiazolyl Thioether → D-Phenylalanyl-Ornithinyl 2-Benzothiazolyl Thioether Trifluoroacetate

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Reaction Steps

Boc-D-phenylalanyl-Nδ-CBz-ornithinyl 2-benzothiazolyl thioether (A) was stirred at 25° C. with trifluoroacetic acid-triethylsilane (3:1-10 ml) for 2 hrs and concentrated in vacuo. The crude residue was purified by HPLC.(method C, retention time=49.57 min); 1H NMR (400 MHz, D2O) δ1.46 (m, 3H), 1.74 (m, 1H), 2.98 (m, 2H), 3.22 (m, 2H), 3.40 (dd, J=13.6; 8.0 Hz, 1H), 3.66 (d, J=14.0 Hz, 1H), 4.17 (m, 2H), 7.30 (m, 2H), 7.44 (m, 3H), 7.52 (t, J=8.0 Hz, 1H), 7.62 (t, J=7.2 Hz, 1H), 7.94 (d, J=8.4 Hz, 1H), and 8.02 (d, J=8.4 Hz, 1H).

Provenance & Evidence