(2S)-2-(((tert-butoxy)carbonyl)amino)-4-phenylbutanoic acid → Boc-Homophenylalanyl-Ndelta-Boc-Nalpha-Methylornithinyl 2-Naphthyl Ether

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Using Procedure D, coupling of Nδ-Boc-Nα-methylornithinyl 2-naphthyl ether (E) and Boc-homophenylalanine afforded titled compound as a glassy solid: 1H NMR (400 MHz, CDCl3) δ1.44 (2s, 18H), 1.58-1.70 (m, 4H), 1.98 (m, 2H), 2.73 (m, 2H), 2.83 (s, 3H), 3.18 (m, 2H), 4.08 (m, 2H), 4.61 (m, 1H), 7.09 (m, 2H), 7.35 (m, 5H), 7.49 (t, J=9.1 Hz, 1H), 7.59 (t, J=9.0 Hz, 1H), and 7.81 (3H).

Provenance & Evidence