HRID1067104

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)O

HCID90234

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

C15H21NO5

结构：CN[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)Oc1ccc2ccccc2c1

HCID131722660

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)[C@H](COCc1ccccc1)NC(=O)OC(C)(C)C)[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)Oc1ccc2ccccc2c1

HCID131722662

未命名化合物

收率 96.1%

PROCEDURE

实验过程

Using Procedure D, crude Nδ-Boc-Nα-methylornithinyl 2-naphthyl ether (37 mg) and Boc-O-benzylserine (62 mg) was coupled to afford product (62 mg) as a colorless oil: 1H NMR (400 MHz, CDCl3) δ1.49 (broad s, 21H), 1.77 (m, 1H), 3.08 (s, 3H), 3.17 (s, 2H), 3.64 (m, 2H), 4.05 (dd, J=13.0; 3.8 Hz, 1H), 4.14 (dd, J=13.0; 7.3 Hz, 1H), 4.52 (m, 3H), 4.91 (m, 1H), 7.05 (m, 2H), 7.20 (m, 3H), 7.32 (m, 3H), 7.41 (m, 1H), and 7.69 (m, 3H); mass spectrum (ES+) m/e 636 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-89ce8c981e10418e9abfe6b84b448b3e
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06245746B1
来源说明: uspto-grants-2001_06

反应 SMILES

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12](=[O:27])[C@H:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[NH:14][CH3:15].[C:28]([NH:35][C@H:36]([C:46](O)=[O:47])[CH2:37][O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12](=[O:27])[C@H:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]([O:22][C:23]([CH3:24])([CH3:26])[CH3:25])=[O:21])[N:14]([C:46](=[O:47])[C@H:36]([CH2:37][O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[NH:35][C:28]([O:30][C:31]([CH3:34])([CH3:32])[CH3:33])=[O:29])[CH3:15]