L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- → Boc-Tyrosyl-Ndelta-Boc-Nalpha-Methylornithinyl 2-Naphthyl Ether

Participants

Reaction Steps

Using Procedure D, crude Nδ-Boc-Nα-methylornithinyl 2-naphthyl ether (133 mg) and Boc-tyrosine (222 mg) is coupled to afford intermediate (125 mg) as a glassy solid: 1H NMR (400 MHz, CDCl3) δ1.44 (m, 21H), 1.63 (m, 1H), 2.75 (s, 3H), 3.15 (m, 2H), 3.92 (m, 2H), 4.84 (m, 1H), 5.06 (m, 1H), 6.62 (d, J=10.2 Hz, 2H), 7.08 (m, 4H), 7.35 (m, 1H), 7.42 (m, 1H), 7.66 (d, J=10.9 Hz, 1H), and 7.75 (m, 3H).

Provenance & Evidence