Trifluoroacetic acid → Tyrosyl-Nalpha-Methylornithinyl 2-Naphthyl Ether Trifluoroacetate

Participants

Reaction Steps

Boc-Tyrosyl-Nδ-Boc-Nα-methylornithinyl 2-naphthyl ether (125 mg) was treated with trifluoroacetic acid (Procedure E) to afford titled product (100 mg) as a white solid: 1H NMR (400 MHz, D2O) δ1.77 (m, 4H), 2.78 (m, 3H), 3.08 (m, 4H), 4.06 (dd, J=11.4; 3.6 Hz, 1H), 4.17 (dd, J=1 1.5; 8.4 Hz, 1H), 4.72 (t, J=7.8 Hz, 1H), 4.89 (m, 1H), 6.65 (d, J=10.8 Hz, 2H), 7.17 (d, J=10.8 Hz, 2H), 7.22 (dd, J=9.6; 1.1 Hz, 1H), 7.34 (s, 1H), 7.51 (t, J=8.4 Hz, 1H), 7.61 (t, J=8.4 Hz, 1H), 7.94 (m, 3H).

Provenance & Evidence