3-Methyl-2,4-pentanedione → HCID 763536, compound

HRID 1067144Notes

Reaction equation

HRID 1067144 reaction equation
[CH3:1][CH:2]([C:6](=O)[CH3:7])[C:3](=O)[CH3:4].[NH2:9][C:10]1[CH:14]=[C:13]([CH3:15])[NH:12][N:11]=1>C(O)(=O)C>[CH3:15][C:13]1[CH:14]=[C:10]2[N:9]=[C:3]([CH3:4])[C:2]([CH3:1])=[C:6]([CH3:7])[N:11]2[N:12]=1

Participants

4

Reactant 2

HCID 699493-Methyl-2,4-pentanedioneHCID 931461H-Pyrazol-3-amine, 5-methyl-

Product 1

HCID 763536HCID 763536, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

12.6 g of 3-methyl-2,4-pentanedione, 30 cc of acetic acid and 9.6 g of 3-amino-5-methylpyrazole were introduced into a 100 ml three-necked round-bottomed flask fitted with a magnetic stirrer, a condenser and a thermometer. The medium was refluxed for 1 hour. The acetic acid was evaporated off and the product was taken up in 50 cc of petroleum ether. The solid was filtered off and washed with petroleum ether. Drying under vacuum and over phosphoric anhydride yielded 15 g of 2,5,6,7-tetramethylpyrazolo[1,5-a]pyrimidine (yield=85.7%).

Workup

  1. customfitted with a magnetic stirrer, a condenser
  2. temperatureThe medium was refluxed for 1 hour
  3. customThe acetic acid was evaporated off
  4. filtrationThe solid was filtered off
  5. washwashed with petroleum ether
  6. dry with materialDrying under vacuum and over phosphoric anhydride

Sources & evidence

ORD record
ord-d1e7e3c30bf047d984d2d57487a97c1a
Source dataset
uspto-grants-2001_06
Patent number
US06248137B1

Reaction notes

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