2,2,6,6-Tetramethyl-3,5-heptanedione → HCID 21192075, compound

Participants

Reaction Steps

36.85 g of 2,2,6,6-tetramethyl-3,5-heptanedione, 200 cc of acetic acid and 32.91 g of 4-nitro-2H-pyrazol-3-ylamine hydrochloride (prepared in accordance with H. Dorn and H. Dilcher, Liebigs Ann. Chem., 707,141, 1967) were introduced into a 500 ml three-necked flask fitted with a condenser, a thermometer and a magnetic bar. The mixture was refluxed for 8.5 hours. The solution was poured, hot, onto ice. The yellow solid which precipitated was filtered off. It was recrystallized from an acetic acid/water mixture. Drying under vacuum and over phosphoric anhydride yielded 25.4 g of 5,7-di-tert-butyl-3-nitropyrazolo[1,5-a]pyrimidine (yield=46%).

Provenance & Evidence