Tetraethylene Glycol → HCID 14691830, compound

Participants

Reaction Steps

18.16 g (128.7 mmol) of 4-fluoronitrobenzene is added to 100 g (515.0 mmol) of tetraethylene glycol, 73 g (1300 mmol) of finely powdered potassium hydroxide and 500 mg of tetrabutylammonium hydrogen sulfate in 500 ml of toluene at 0° C., and it is stirred overnight at room temperature. 1000 ml of saturated common salt solution is; added, the organic phase is separated and it is dried on magnesium sulfate. It is evaporated to dryness in a vacuum, and the residue is chromatographed in silica gel (mobile solvent: methylene chloride/isopropanol=15:1).

Provenance & Evidence