Dichloromethane → HCID 12043850, compound

Participants

Reaction Steps

A suspension of 3.63 9 (10 mmol) of (2d) and 0.36 g 10% Pd/C in 160 ml DMA was left under 2.7 atm hydrogen pressure for 24 h. The product was soluble in DMA. Pd/C was filtered away with celite. The filtrate was poured onto ice-water and pH was increased to basic with 20% KOH, which resulted in a brown precipitate. The precipitate was chromatographied in 20% MeoH/CH2Cl2, which resulted in 2.80 g of the product (3d).

Provenance & Evidence