Hydrochloric Acid → HCID 178512629, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (5-benzyloxyisoquinolin-1-yl)guanidine (290 mg, 1.0 mmol) in EtOH (10 mL) containing 10% Pd-C (60 mg) and dilute HCl (1.5 mL, 2 M, 3.0 mmol) was stirred under an atmosphere of H2 (4 atmospheres) at 60° C. for 3 d. An additional portion of catalyst (30 mg) and HCl (0.5 mL) were added and hydrogenation continued for a further 3 d. The mixture was filtered through Arbocel with EtOH rinsing, the filtrate was evaporated in vacuo and the residue purified by column chromatography upon silica gel using dichloromethane:methanol:0.88 ammonia (90:10:1 to 84:14:2) as eluant to give (5-hydroxyisoquinolin-1-yl)guanidine (66 mg, 0.33 mmol) as a white solid.

Provenance & Evidence