Guanidine Hydrochloride → HCID 178512627, compound

Participants

Reaction Conditions

Reaction Steps

Guanidine hydrochloride (100 mg, 1.05 mmol) was added in one portion to a suspension of sodium hydride (NaH) (30 mg, 80% dispersion by wt. in mineral oil, 1.0 mmol) in dimethylsulphoxide (DMSO) (3.5 mL) and the mixture was heated at 60° C. under nitrogen (N2) for 30 minutes. 1-Chloro-7-phenylsulphamoylisoquinoline (110 mg, 0.345 mmol) was added and the mixture was heated at 100° C. for 3 d. The solvents were evaporated in vacuo and the residue was purified by column chromatography (silica gel using CH2Cl2-methanol-0.880NH3 (97:3:0.3 to 90:10:1) as eluant) to give 1-guanidino-7-phenylsulphamoylisoquinoline (16 mg, 0.047 mmol) as an off-white solid.

Provenance & Evidence