HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Chloroisoquinoline-5-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Chloroisoquinoline-5-sulfonic acid | HCID 13730020 | — |
| Product | 1-Chloroisoquinoline-5-sulfonyl chloride | HCID 21979781 | — |
Reaction Steps
A suspension of 1-chloro-5-isoquinolinesulphonic acid (1.14 g, 4.68 mmol) in thionyl chloride (13 mL) and DMF (0.3 mL, 3.9 mmol) was heated to reflux for 3 h. Concentration in vacuo and azeotroping with toluene gave 1-chloro-5-chlorosulphonylisoquinoline as an off-white solid which was used immediately.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248738B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-f43a5f12e3d040d1bd5f309686b170a0 |
| Source note | uspto-grants-2001_06 |