反应详情

7-chlorosulphonyl-1,4-dichloroisoquinoline (110 mg, 0.37 mmol) was dissolved in a solution of saturated methanolic ammonia (NH3) (10 mL) and the solution stirred at room temperature for 1.5 hours. The solvents were evaporated in vacuo and the residue was azeotroped with CH2Cl2 and then partitioned between EtOAc and water. The organic phase was washed with brine, dried (MgSO4) and evaporated in vacuo to give 1,4-dichloro-7-sulphamoylisoquinoline (98 mg, 0.35 mmol) as a white solid.

1. customThe solvents were evaporated in vacuo
2. customthe residue was azeotroped with CH2Cl2
3. custompartitioned between EtOAc and water
4. washThe organic phase was washed with brine
5. dry with materialdried (MgSO4)
6. customevaporated in vacuo