4-Chlorobenzylamine → HCID 21192417, compound

Participants

Reaction Steps

A slurry of 1.11 g of ethyl 1-(tert-butyl)-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylate from Preparation No. 9 in 2.0 g of 4-chlorobenzylamine is heated under argon at 160° C. for 18 hours, then cooled to room temperature and triturated with 1N HCl. The solid is filtered, washed well with water, and dried under vacuum. Flash chromatography using 20% ethyl acetate in dichloromethane provides 1.22 g of the title compound as a white solid.

Provenance & Evidence