HCID 16073857, compound → HCID 9823825, compound

Participants

Reaction Steps

A mixture of 303 mg of 1-(tert-butyl)-N-(4-chlorobenzyl)-6-(3-hydroxy-1-propynyl)-4-oxo-1,4-dihydro-3-quinolinecarboxamide from Preparation No. 11 and 15 mg of platinum oxide in 10 mL of 1: 1 THF-methanol is stirred under 1 atm of hydrogen gas for 3 h, then filtered through diatomaceous earth and concentrated under reduced pressure. The mixture was purified by flash chromatography on silica using 2-3% methanol in dichloromethane to afford 294 mg of the title compound.

Provenance & Evidence