HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1067273Generated: October 27, 2026
Ethanol → Ethyl 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylate
https://huagongshe.com/reaction/1067273
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 8-Amino-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid | HCID 21193470 | — |
| Product | Ethyl 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylate | HCID 15817382 | — |
Reaction Steps
23.5 g (0.198 mol) of thionyl chloride are introduced slowly into a 2 1 three-necked round-bottomed flask containing 772 ml of ethanol cooled to −40° C., with stirring, the stirring is continued at this temperature for 1 h, 38.6 g (0.198 mol) of 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid dissolved in 100 ml of ethanol are added slowly, over 15 min, and the mixture is allowed to warm to room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06248757B1 |
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| Source dataset | uspto-grants-2001_06 |
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| ORD ID | ord-a108d9fd0230480ab3e8f9c06dfca9ad |
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| Source note | uspto-grants-2001_06 |
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