Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydracrylonitrile | HCID 8011 | — |
| Reactant | Ethyl 3-oxovalerate | HCID 78656 | — |
| Reactant | HCID 54149837 | HCID 54149837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22725151 | HCID 22725151 | 73.4% |
Reaction Steps
2-Cyanoethyl 3-{(4-nitrophenyl)methylene}-4-oxopentanoate. A mixture of ethyl propionylacetate (25 g, 0.173 mol) and 3-hydroxypropionitrile (18.48 g, 0.26 mol) was stirred and heated at 200-205° C. for 2 h and the ethanol formed was removed by distillation. The residue was subjected to high vacuum distillation and the fraction distilling at 120-125° C. 0.4 mm of Hg was collected to get 2-cyanoethyl propionylacetate (21.5 g, 73.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06248747B1 |
|---|
| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-19f299bafb7d4895874f5fe24fd4aafd |
|---|
| Source note | uspto-grants-2001_06 |
|---|
