Potassium Carbonate → HCID 21192936, compound

Participants

Reaction Steps

A solution of N-(8-chloro-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-bromo-4-ethoxybenzamide (0.28 g) in methanol/water (5 ml 9:1) was treated with potassium carbonate (0.38 g) and stirred 12 h. The mixture was diluted with dichloromethane and washed with water. The organic phase was dried (MgSO4) solvent removed at reduced pressure. The residue was chromatographed (silica gel, dichloromethane/methanol/ammonia up to 9:1:0.1 eluant) to give the title compound (0.18 g) as a colourless solid.

Provenance & Evidence