Formaldehyde → HCID 21192926, compound

Participants

Reaction Steps

A solution of N-(8-Chloro-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-bromo-4-ethoxybenzamide (0.12 g) in 37% aqueous formaldehyde (0.63 ml) and formic acid (0.34 ml) and stirred at 80° C. for 3 h. Solid sodium hydroxide was added to neutralise the solution and the aqueous phase extracted with dichloromethane. The combined organic extracts were dried (MgSO4) and solvent removed in vacuo to give the title compound (0.11 g).

Provenance & Evidence