Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | HCID 21192918 | HCID 21192918 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Product | HCID 21192923 | HCID 21192923 | — |
Reaction Steps
N-(8-Bromo-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-methoxy-3-trifluoromethylbenzamide (0.25 g), was combined with lithium chloride (0.06 g), tetramethyltin (0.08 ml) and bis(triphenylphosphine)palladium(II)chloride (0.025 g) in dimethylformamide (5 ml) and the mixture warmed to 100° C. for 24 h. Solvent was removed at reduced pressure, filtered (Celite pad) and the filtrate column chromatographed (silica gel, diethyl ether eluant) to give N-(8-methyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4methoxy-3-trifluoromethylbenzamide (0.16 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06248754B1 |
|---|
| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-9a4ef05fc6454c108aed72a616c47854 |
|---|
| Source note | uspto-grants-2001_06 |
|---|
